Endocrine Abstracts

Introduction and objectives: The aim of this study was to evaluate the risk of death in relation to hemodialysis.Material and methods: We performed a 10-month follow up study of hemodialysed patients attending our Center. A total of 97 patients were evaluated: 37 (38.1%) nephroangiosclerosis, 28 (28.9%) diabetic nephropathy, 18 (18.6%), and glomerulonephritis 14 (14.4%) other causes. Somatic sensory neuropathy (PN) was documented using the Neuropathy Dis...

Introduction: Hypercalcemia has a broad differential, including primary hyperparathyroidism, non-parathyroid hormone-mediated hypercalcemia, including humoral hypercalcemia of malignancy, or medication mediated. We report a case of severe hypercalcemia attributable to milk-alkali syndrome due to excessive calcium carbonate use.Case: A 71 year-old female with a history of hypertension presented after a fall without loss of consciousness. She endorsed epis...

Introduction: Primary aldosteronism (PA) is characterized by symptoms caused by hypertension and hypokalemia. Some cardiovascular events are found to be more common due to the additional negative effect of aldosterone. The aim of the study was to analyse clinical characteristics of the PA due to adenoma (APA) and to compare the frequency of cardiovascular diseases with those found in adrenal Cushing’ syndrome (CS) and adrenal adenoma associated with essential hypertension...

Polycystic ovary syndrome (PCOS) is characterized by excessive androgen secretion and women with PCOS are at risk of developing anxiety disorders. Maternal testosterone levels in humans have been shown to affect brain development and to be correlated to mental function. During pregnancy, women with PCOS display high circulating androgen levels that may affect the fetus and increase the risk of mood disorders in offspring. This study investigated whether maternal androgen exces...

Introduction: The aim of this study was to determine whether sentinel lymph node (SLN) biopsy of jugulo-carotid chain (JCC) in thyroid microcarcinomas (TMC) is an accurate technique to select patients with true positive, but clinically and ultrasonically N0 LNs, for modified radical neck dissection (MRND).Materials and methods: In total 199 patients with TMC underwent total thyroidectomy, central neck dissection and SLN mapping with 0.2 ml of 1% methylen...

Background: Papillary thyroid carcinoma in children and adolescents is rare but it shows aggressive behavior. Gross lymph node metastases and distant metastases are common on first clinical presentation.Patients and methods: Forty-eight children and adolescents were operated due to PTC. Mean age was 16.6 years (range 7–21). At the time of diagnosis 13% had lung metastases. Total thyroidectomy or completion of thyroidectomy was performed in all cases...

Thyrotoxic periodic paralysis (TPP) is uncommon complication of Graves’ disease mainly observed in young males of Asian origin. It is rarely seen among white hyperthyroid patients (0.1–0.2%), usually presented as lower extremities muscle weakness of sudden onset, probably cause by hypokalemia. Possible mechanism of hypokalemia is an increased sodium–potassium–adenosine triphosphatase pump activity with consequent massive shift og potassium from extracellula...

Aim of this study was to evaluate biochemical parameters of thyroid gland function, used in evaluation of levothyroxine (L-T4) dose titration during a long time period in hypothyroid patients.Patients and methods: About 32 hypothyroid women were included in our study. All patients were euthyroid for a long time, treated with levothyroxine replacement therapy, taking an individually titrated daily dosage (50–100 μg). Blood samples...

Background: Diabetic nephropathy affects 20–40% diabetics. It is the most common cause of ESRD in Europe. In Serbia, 10–18% of the patients requiring HD are diabetics and that number is constantly increasing.Methods: We made a retrospective study of the survival of both diabetic and non-diabetic patients requiring HD treatment during two 5 years long periods.Results: During the first period 92 patients were followed-up an...

Background: Gaucher disease (GD) is the most common lysosomal storage disorder. The defect is deficiency of lysosomal glucocerebrosidase (GBA), due to biallelic mutations in GBA gene, characterized by the deposition of GBA in cells of the macrophage-monocyte system.Objective: To report clinical phenotypes of GD and correlate with GBA gene mutations, and to identify GBA gene mutation in patients diagnosed with GD in Montenegro.Metho...